Mechanism of Inhibitory Action of Tranilast on the Release of Slow Reacting Substance of Anaphylaxis (SRS-A) In Vitro: Effect of Tranilast on the Release of Arachidonic Acid and Its Metabolites

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Mechanism of inhibitory action of tranilast on the release of slow reacting substance of anaphylaxis (SRS-A) in vitro: effect of tranilast on the release of arachidonic acid and its metabolites.

We investigated the mechanism of inhibitory action of tranilast, one of the anti-allergic drugs, on the release of slow reacting substance of anaphylaxis (SRS-A). Ionophore A23187 (0.5 or 0.2 micrograms/ml)-induced SRS-A release from rat peritoneal exudate cells (PEC) or human leucocytes was inhibited by tranilast (10(-5)-10(-3) M). The IC50 (the concentration which gives 50% inhibition) of tra...

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ژورنال

عنوان ژورنال: Japanese Journal of Pharmacology

سال: 1988

ISSN: 0021-5198

DOI: 10.1016/s0021-5198(19)43350-7